Journal of medicinal chemistry

N-(4-Substituted-thiazolyl) oxamic acid derivatives, new series of potent, orally active antiallergy agents

KD Hargrave, FK Hess, JT Oliver

文献索引：Hargrave, Karl D.; Hess, Friedrich K.; Oliver, James T. Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1158 - 1163

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被引用次数: 225

摘要

A series of N-(4-substituted-thiazolyl) oxamic acid derivatives were synthesized and tested for antiallergy activity in the rat PCA model. These compounds were conveniently prepared by treatment of the appropriate acetophenone with thiourea and iodine or by reaction of the chloroacetylbenzene with thiourea to give the corresponding aminothiazoles; subsequent condensation with ethyloxalyl chloride gave the thiazolyloxamates. Many of the analogues ...