Synthesis and Anti-HIV-1 Activity of 4, 5, 6, 7-Tetrahydro-5-methylimidazo [4, 5, 1-jk][1, 4] benzodiazepin-2 (1H)-one (TlBO) Derivatives. 4

W Ho, MJ Kukla, HJ Breslin, DW Ludovici…

文献索引：Ho; Kukla; Breslin; Ludovici; Grous; Diamond; Miranda; Rodgers; De Clercq; Pauwels; Andries; Janssen Journal of Medicinal Chemistry, 1995 , vol. 38, # 5 p. 794 - 802

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被引用次数: 81

摘要

In previous papers, we have described the discovery of a new series of compounds, 4, 5, 6, 7-tetrahydro-5-methylimidazo [4, 5, l~~ l [l, 4lbenzodiazepin-2 (~-ones, TlBO (1 and la), with potent anti-HW-1 activity and the synthesis of analogues to better define the structure-activity relationships (SAR) in terms of changes in substituents at the N-6 position and variations of the five-membered urea ring as well as the seven-membered diazepine ring. This paper ...