Bioorthogonal Probes for Polo??like Kinase 1 Imaging and Quantification

…, KS Yang, T Reiner, R Weissleder

文献索引：Budin, Ghyslain; Yang, Katherine S.; Reiner, Thomas; Weissleder, Ralph Angewandte Chemie - International Edition, 2011 , vol. 50, # 40 p. 9378 - 9381

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被引用次数: 45

摘要

Polo-like kinase 1 (PLK1) is a critical mediator of the cell cycle, regulating mitotic progression. Specific functions of PLK1 during mitosis include chromosome segregation, centrosome maturation, bipolar spindle formation, regulation of the anaphase-promoting complex/cyclosome (APC/C), coordination of cytokinesis, and regulation of the DNA damage checkpoint.[1–3] This serine/threonine kinase also plays an essential role in mitotic entry ...