Diazines 13: Metalation without Ortho-Directing Group-Functionalization of Diazines via Direct Metalation

…, A Turck, K Couture, G Queguiner

文献索引：Ple, Nelly; Turck, Alain; Couture, Karine; Queguiner, Guy Journal of Organic Chemistry, 1995 , vol. 60, # 12 p. 3781 - 3786

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被引用次数: 71

摘要

The successful metalation of diazines without an ortho-directing group is described. In some cases, dimers were obtained. The metalation was optimal with LTMP if a 4-fold excess of metalating agent was used, with a very short metalation reaction time at-75" C. This procedure was applied to pyrimidine, 2-substituted pyrimidines, pyridazine, and pyrazine, allowing for the synthesis of various monosubstituted diazines.