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Fluorinated sugar analogs of potential anti-HIV-1 nucleosides

…, LC Chen, L Wang, MH Kim, JA Warshaw…

文献索引：Huang; Chen; Wang; Kim; Warshaw; Armstrong; Zhu; Chou; Watanabe; Matulic-Adamic; Su; Fox; Polsky; Baron; Gold; Hardy; Zuckerman Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1640 - 1646

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被引用次数: 53

摘要

In order to obtain agenta with therapeutic indices superior to those of AZT, FLT, or D4T, several analogues of anti-HIV-1 nucleosides were synthesized. These include 2', 3'-dideoxy- 2', 3'-difluoro-5-methyluridine (13), ita arabino analogue 19, arabino-5-methylcytosine analogue 21, 3'-deoxy-2', 3'-didehydro-2'-fluorothymidine (25), Y-azido-2', 3'-dideoxy-2'- fluoro-5-methyluridine (29), 2'-azido-3'-fluoro-2', 3'-dideoxy-5-methyluridine (31), and 2', 3' ...

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[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate结构式

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[(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate结构式

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132776-17-1

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1-[(2R,3S,4R,5R)-3,4-difluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione结构式

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1-[(2R,3S,4R,5R)-3,4-difluoro-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione结构式

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132776-24-0

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5-甲基尿甙结构式

1463-10-1

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132776-24-0

1-[(2R,3R,4R,5R...

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1-[(2R,3S,4S,5R)-3-azido-4-fluoro-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione结构式

132776-26-2

1-[(2R,3S,4S,5R...

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132776-27-3

1-[(2R,3S,4S,5R...

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115913-84-3

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1-[(2R,3S,4S,5R)-3-azido-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione结构式

132776-27-3

1-[(2R,3S,4S,5R...

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1-[(2R,3R,4R,5R)-3-azido-4-hydroxy-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione结构式

132776-24-0

1-[(2R,3R,4R,5R...

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1-[(2R,3S,4S,5R)-3-azido-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione结构式

132776-27-3

1-[(2R,3S,4S,5R...

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[(2R,3R,4R,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-4-methylsulfonyloxy-2-(trityloxymethyl)oxolan-3-yl] methanesulfonate结构式

124493-84-1

[(2R,3R,4R,5R)-...

~%

1-[(2R,3S,4S,5R)-3-azido-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione结构式

132776-27-3

1-[(2R,3S,4S,5R...

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5-甲基尿甙结构式

1463-10-1

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1-[(2R,3S,4S,5R)-3-azido-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione结构式

132776-27-3

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