Potential neuroleptics of the orthopramide series; synthesis of N-substituted 5-(aminosulfonyl)-2-methoxybenzamides

V Valenta, M Protiva

文献索引：Valenta, Vladimir; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 8 p. 2095 - 2106

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被引用次数: 6

摘要

Abstract The mixed anhydride of 5-(aminosulfonyl)-2-methoxybenzoic acid (VII) and monoethyl carbonate reacted with benzylamine, 1-methylpiperazine, and 1- benzylpiperazine to give the 5-(aminosulfonyl)-2-methoxybenzamides II, IV, and V. Heating the ethyl ester X with 4-amino-1-methyl-piperidine resulted in the amide III. Reaction of 5- (chlorosulfonyl)-2-methoxybenzoyl chloride (XI) with 1-benzylpiperazine afforded 5-(4- ...