Bioorganic & medicinal chemistry letters

Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease

LG Ulysse, J Chmielewski

文献索引：Ulysse, Luckner G.; Chmielewski, Jean Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3281 - 3286

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被引用次数: 26

摘要

Interfacial peptides of HIV-1 protease were crosslinked with varying length alkyl-chains containing either a single cis or trans double bond, or a triple bond to remove degrees of freedom within the tethers. The synthesis of these compounds and their effects on the activity of HIV-1 protease are described.