Partly reduced biphenyls as central nervous system agents. 2. cis-and trans-4-Arylcyclohexylamines

D Lednicer, DE Emmert, R Lahti…

文献索引：Lednicer,D. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, # 12 p. 1239 - 1243

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被引用次数: 11

摘要

Both isomers of 4-(p-fluorophenyl) cyclohexylamine were prepared and their stereochemical identities determined. A series of trans-4-arylcyclohexylamines was synthesized by a stereoselective route starting from the Grignard reaction product of 4-hy drox~ cyclohexanone with substituted bromobenzenes. The amines were then converted to piperidines and 4-fluoro-4-butyrophenones. The products were tested in a series of ...