In the search for new potent antiparasitical fluoroquinolones, a QSAR analysis by molecular connectivity led to the design of R5 (Me or Et)/R8 (MeO, Me or Et)-substituted analogs of the most powerful antibacterial or antiparasitical fluoroquinolones known so far. Unfortunately, the synthetic schemes that were elaborated in literature for 3-and 3, 6-di-substituted 2, 4, 5- trifluorobenzoic acids, the key precursors of the target R5/R8-substituted 6- ...
