Chemical and pharmaceutical bulletin

Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors.

H Shih, HB Cottam, DA Carson

文献索引：Shih, Hsiencheng; Cottam, Howard Brinkerhoff; Carson, Dennis Anthony Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 3 p. 364 - 367

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被引用次数: 11

摘要

A facile synthesis of 9-substituted 9-deazapurines as potential inhibitors of purine nucleoside phosphorylase has been achieved by the direct Friedel–Crafts aroylation or arylmethylation of 9-deazapurines using trifluoromethanesulfonic acid as catalyst. The aroylated 9-deazapurines could be transformed into the corresponding 9-arylmethyl derivatives by the Wolff–Kishner reaction. A novel synthesis of 9-deazahypoxanthine was ...