Synthesis of eosinophil infiltration inhibitors with antihistaminic activity.

…, H Nagaya, S Fukuda, Y Ashida, Y Kawano

文献索引：Gyoten, Michiyo; Nagaya, Hideaki; Fukuda, Shigeru; Ashida, Yasuko; Kawano, Yasuhiko Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 2 p. 122 - 133

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被引用次数: 24

摘要

A series of [1, 2, 4] triazolo [1, 5-b] pyridazines (5) and imidazo [1, 2-b] pyridazines (6) having cyclic amines was synthesized and evaluated for antihistaminic activity and inhibitory effect on eosinophil infiltration. When a piperidine or a piperazine containing a benzhydryl group and a suitable spacer was incorporated at the 6-position, the fused pyridazines were found to exhibit both antihistaminic activity and an inhibitory effect on eosinophil chemotaxis. ...