An entirely new synthesis of the important benzimidazole building block BYK308944 was elaborated using the Stobbe reaction as central element. BYK308944 constitutes an important intermediate for the preparation of 3, 6, 7, 8-tetrahydrochromeno [7, 8-d] imidazoles as potassium-competitive acid blockers. The new route relies on the hydroxymethylation of 1, 2-dimethylimidazole as cheap starting material followed by ...
