Tetrahedron letters

Highly enantioselective alkylation of glycine methyl and ethyl ester derivatives under phase-transfer conditions: its synthetic advantage

T Ooi, Y Uematsu, K Maruoka

文献索引：Ooi, Takashi; Uematsu, Yukitaka; Maruoka, Keiji Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1675 - 1678

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被引用次数: 46

摘要

Phase-transfer alkylation of the benzophenone Schiff base of glycine methyl or ethyl ester () was found to be catalyzed by 3, 4, 5-F3-C6H2-NAS-Br [] with high efficiency and excellent enantioselectivity. This procedure allows facile derivatization of the resulting alkylation products to other synthetically useful chiral building blocks.