Synthetic models related to DNA intercalating molecules: comparison between quinacrine and chloroquine in their ring-ring interaction with adenine and thymine

…, C Demuynck, MF Lhomme, J Lhomme…

文献索引：Bolte; Demuynck; Lhomme; et al. Journal of the American Chemical Society, 1982 , vol. 104, # 3 p. 760 - 765

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被引用次数: 26

摘要

Abstract: Stacking interactions between the acridine ring of the antimalarial drug quinacrine and the nucleotide bases, adenine and thymine, have been studied by preparing and examining models in which the acridine is linked to the base by a trimethylene bridge. The degree of intramolecular ring-ring stacking interaction in water has been determined by hypochromism measurement in the UV and by 270-MHz 'H NMR spectroscopy. We show ...