2-Amino-[1, 2, 4] triazolo [1, 5-a] pyridines as JAK2 inhibitors

…, JZ Chen, C Eigenbrot, N Ghilardi, P Gibbons…

文献索引：Siu, Michael; Pastor, Richard; Liu, Wendy; Barrett, Kathy; Berry, Megan; Blair, Wade S.; Chang, Christine; Chen, Jacob Z.; Eigenbrot, Charles; Ghilardi, Nico; Gibbons, Paul; He, Haiying; Hurley, Christopher A.; Kenny, Jane R.; Cyrus Khojasteh; Le, Hoa; Lee, Leslie; Lyssikatos, Joseph P.; Magnuson, Steve; Pulk, Rebecca; Tsui, Vickie; Ultsch, Mark; Xiao, Yisong; Zhu, Bing-Yan; Sampath, Deepak Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 17 p. 5014 - 5021

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被引用次数: 14

摘要

JAK2 (Janus kinase 2) is a member of a family of non-receptor cytoplasmic tyrosine kinases which include JAK1, JAK3, and TYK2. 1 This family of kinases share similar structural motifs, and all have a JH1 kinase domain at the C terminus with an adjacent JH2 pseudokinase domain. The JAK/TYK kinases are activated upon cytokine to cytokine receptor binding. Transduction of the cytokine signal occurs by phosphorylation of STAT (signal transducers and activators of ...