Bioorganic & medicinal chemistry

Novel amide-and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases

KP Bhabak, C Arenz

文献索引：Bhabak, Krishna P.; Arenz, Christoph Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 20 p. 6162 - 6170

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被引用次数: 12

摘要

In the present study we describe the design and synthesis of a series of amide-and sulfonamide-based compounds as inhibitor of recombinant acid and neutral ceramidases. Inhibition of ceramidases has been shown to induce apoptosis and to increase the efficacy of conventional chemotherapy in several cancer models. B-13, lead in vitro inhibitor of acid ceramidase has been recently shown to be virtually inactive towards lysosomal acid ...