1-Aryl-2-(aminomethyl) cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants

B Bonnaud, H Cousse, G Mouzin, M Briley…

文献索引：Bonnaud, Bernard; Cousse, Henri; Mouzin, Gilbert; Briley, Mike; Stenger, Antoine; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 318 - 325

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被引用次数: 62

摘要

322 Journal of Medicinal Chemistry, 1987, Vol. 30, No. 2 carboxamide) and decreased with further lengthening of the carbon chain. The immediate inferior (24) and superior (32) homologues of the clinically active compound 25 were at least 10-fold less active in the yohimbine test. Certain cyclic carboxamides were synthesized to see whether the steric hinderance had any effect on the potency. The activity of these derivatives (36-38) was ...