Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro

J Ravindran, GV Subbaraju, MV Ramani, B Sung…

文献索引：Ravindran, Jayaraj; Subbaraju, Gottumukkala V.; Ramani, Modukuri V.; Sung, Bokyung; Aggarwal, Bharat B. Biochemical Pharmacology, 2010 , vol. 79, # 11 p. 1658 - 1666

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被引用次数: 52

摘要

Curcumin, a component of turmeric (Curcuma longa), exhibits anti-inflammatory and anti- proliferative activities through the generation of reactive oxygen species (ROS). Curcumin (diferuloylmethane) contains two hydroxyl, two methoxy and two phenyl groups but how these groups contribute to its activity is poorly understood. We synthesized analogues that varied in inclusion of these groups and compared their activity. We found that ...