Cyanation of arenes via iridium-catalyzed borylation

CW Liskey, X Liao, JF Hartwig

文献索引：Liskey, Carl W.; Liao, Xuebin; Hartwig, John F. Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11389 - 11391

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被引用次数: 112

摘要

We report a method to conduct one-pot meta cyanation of arenes by iridium-catalyzed C− H borylation and copper-mediated cyanation of the resulting arylboronate esters. This process relies on a method to conduct the cyanation of arylboronic esters, and conditions for this new transformation are reported. Conditions for the copper-mediated cyanation of arylboronic acids are also reported. By the resulting sequence of borylation and cyanation, 1, 3- ...