Synthesis of 2-amino-4-(7-azaindol-3-yl) pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors

S Huang, R Li, PJ Connolly, S Emanuel…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 18 p. 4818 - 4821

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被引用次数: 25

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Solubilizing amino side chains were installed using the chemistry shown in Scheme 2. The hydroxyl compound 5o was reacted with methanesulfonyl chloride to generate mesylate 6, which was then treated with various amines to give ...