An improved synthesis of S-adenosyl-L-homocysteine and related compounds

A Holý, I Rosenberg

文献索引：Holy, Antonin; Rosenberg, Ivan Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1514 - 1518

全文：HTML全文

被引用次数: 5

摘要

Abstract 5'-Chloro-5'-deoxy-2', 3'-O-isopropylideneadenosine reacts with disodium salts of L- homocysteine, L-cysteine or 3-mercaptopropanoic acid in liquid ammonia to afford 2', 3'-O- isopropylidene derivatives which are easily desalted by chromatography on octadecyl-silica column. On acid treatment, the high purity preparations of S-adenosyl-L-homocysteine, S- adenosyl-L-cysteine, and 5'-carboxyethylthio-5'-deoxyadenosine are obtained in ...