Synthesis, biological evaluation, and molecular docking studies of N, 1, 3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents

X Li, X Lu, M Xing, XH Yang, TT Zhao, HB Gong…

文献索引：Li, Xi; Lu, Xiang; Xing, Man; Yang, Xian-Hui; Zhao, Ting-Ting; Gong, Hai-Bin; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3589 - 3593

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被引用次数: 32

摘要

A series of N, 1, 3-triphenyl-1H-pyrazole-4-carboxamide derivatives have been designed, synthesized and evaluated for their potential antiproliferation activity and Aurora-A kinase inhibitory activity. Among all the compounds, compound 10e possessed the most potent biological activity against HCT116 and MCF-7 cell lines with IC50 values of 0.39±0.06 μM and 0.46±0.04 μM, respectively, which were comparable to the positive control. ...