Synthesis and biological evaluation of 6, 7-disubstituted 4-aminopyrido [2, 3-d] pyrimidines as adenosine kinase inhibitors

RJ Perner, CH Lee, M Jiang, YG Gu…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 11 p. 2803 - 2807

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被引用次数: 33

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Medicinal chemistry efforts directed at optimizing the potency and improving the membrane permeability of these AK inhibitors was initiated ... While they share similar calculated physical chemical properties (solubility, clog P, etc), it is this ...