Synthesis

A facile one-pot synthesis of 1-aryl-2-(dimethylaminomethyl) prop-2-en-1-ones from aryl methyl ketones

U Girreser, D Heber, M Schütt

文献索引：Girreser, Ulrich; Heber, Dieter; Schuett, Martin Synthesis, 1998 , # 5 p. 715 - 717

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被引用次数: 6

摘要

Abstract: A generally applicable synthesis of 1-aryl-2-(dimethylaminomethyl) prop-2-en-1- ones 2 involving reaction of aromatic methyl ketones 1 with paraformaldehyde and dimethylamine in dimethylformamide is described. The majority of experiments were conducted with these reagents, but the process can also be performed using dimethyl (methylene) ammonium chloride. Key words: 1-arylprop-2-en-1-ones, Mannich Reaction, ...