Tetrahedron Letters

Specific removal of o-methoxybenzyl protection by DDQ oxidation.

Y Oikawa, T Yoshioka, O Yonemitsu

文献索引：Oikawa, Yuji; Yoshioka, Tadao; Yonemitsu, Osamu Tetrahedron Letters, 1982 , vol. 23, # 8 p. 885 - 888

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被引用次数: 609

摘要

Abstract Methoxybenzyl protecting groups of alcohols were readily and efficiently removed with DDQ in CH 2 Cl 2-H 2 O at room temperature. Under these neutral conditions, other usual protecting groups, isopropylidene, methoxymethyl, benzyloxymethyl, tetrahydropyranyl, acetyl, t-butyldimethylsilyl, benzyl, benzoyl, and tosyl, as well as functional groups, epoxide, double bond, and ketone, were remained unchanged.