Synthesis, conformational properties, and antibody recognition of peptides containing. beta.-turn mimetics based on. alpha.-alkylproline derivatives

…, NGJ Richards, DL Turner, JA Robinson

文献索引：Hinds; Welsh; Brennand; Fisher; Glennie; Richards; Turner; Robinson Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1777 - 1789

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被引用次数: 116

摘要

Peptide recognition by monoclonal antibodies may provide a useful model for drug development, in particular to test the effecta of conformational restriction on ligand binding. We have tested the influence of novel peptide mimetics upon conformation and binding affinity for the case of monoclonal antibodies raised to a peptide antigen which displays a preference for a &turn conformation in aqueous solution. Two monoclonals were isolated ...