The synthesis of phenyl-substituted triazole analogs of histamine

JC Sheehan, CA Robinson

文献索引：Sheehan; Robinson Journal of the American Chemical Society, 1951 , vol. 73, p. 1207,1209

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被引用次数: 33

摘要

Based on the antihistaminic activity shown by the triazole analog of histamine, which was previously reported2 it appeared of interest to extend this investigation to some related compounds. A possible mode of action of antihistaminics is by an antagonism in which a blocking molecule adheres to the cell surface and not only prevents histamine from reaching its site of action but also, by the screening effect of large blocking groups, inactivates ...