Isocytosine H 2-receptor histamine antagonists. III. The synthesis and biological activity of lupitidine (SK&F 93479) and related compounds

…, CR Ganellin, RJ Ife, ME Parsons, DA Rawlings…

文献索引：Brown; Armitage; Blakemore; Blurton; Durant; Ganellin; Ife; Parsons; Rawlings; Slingsby European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 217 - 226

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被引用次数: 19

摘要

Abstract A series of 2-[2-(5-dimethylaminomethyl-2-furanylmethylthio) ethylamino]-4- pyrimidones is described containing a variety of substituents in the 5-position of the pyrimidone (isocytosine) ring. Good H 2-receptor histamine antagonist activity is retained over a range of basic and neutral, polar and non-polar substituents and the majority of compounds are selective for the H 2-receptor. Modifications have also been made to the ...