Synthesis of a novel, recyclable, solid-phase acylating reagent

RB Nicewonger, L Ditto, D Kerr, L Varady

文献索引：Nicewonger, Robert B; Ditto, Lori; Kerr, Doug; Varady, Laszlo Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 14 p. 1799 - 1802

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被引用次数: 25

摘要

In this paper, we describe the synthesis of N-(6-cyano-1, 3-dimethyl-2, 4-dioxo-5-substituted- 1, 3-dihydropyridino [2, 3-d] pyrimidin-7-yl) imides 1. We will show the synthesis of 1 using both conventional heating and microwave techniques. In addition, the imide was attached to polystyrene and this immobilized imide was equally as effective at acylating various primary and secondary amines as its solution-phase counterpart.