3, 4-Dihydro-2-phenyl-2H-pyrano [2, 3-b] pyridines with potent antirhinovirus activity

…, JK Dulworth, MT Kenny, R Massad…

文献索引：Bargar; Dulworth; Kenny; Massad; Daniel; Wilson; Sargent Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1590 - 1595

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被引用次数: 17

摘要

Chemistry. The general synthesis route for the title compounds is outlined in Scheme I. Bromination of 5-chloro-2-methoxypyridine produced the 3-bromo derivative 2a. Similarly, bromination of 2-methoxypyridine with an extra equivalent of bromine gave the dibromopyridine 2b. Bromine-lithium exchange was effected with n-butyllithium in ether at- 70" C, and the intermediate lithiopyridines were trapped with the appropriate cinnam- ...