… xanthine oxidase inhibitory activities of 2-substituted 6-alkylidenehydrazino-or 6-arylmethylidenehydrazino-7H-purines and 3-and/or 5-substituted 9H-1, 2, 4-triazolo [ …

T Nagamatsu, H Yamasaki, T Fujita, K Endo…

文献索引：Nagamatsu, Tomohisa; Yamasaki, Hiroo; Fujita, Takayuki; Endo, Kazuki; HaruhikoMachida Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 21 p. 3117 - 3125

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被引用次数: 10

摘要

The facile and general synthesis of 2-substituted 6-alkylidenehydrazino-or 6- arylmethylidenehydrazino-7H-purines and 3-and/or 5-substituted 9H-1, 2, 4-triazolo [3, 4-i] purines, which were obtained by oxidative cyclisation of the corresponding 6-aldehyde hydrazones of 7H-purine, as a new class of potential xanthine oxidase inhibitors are reported. Their inhibitory activities against bovine milk xanthine oxidase in vitro were also ...