Synthesis and antiherpetic activity of (.+-.)-9-[[(Z)-2-(hydroxymethyl) cyclopropyl] methyl] guanine and related compounds

…, AK Field, J Hannah, JD Karkas, R Liou…

文献索引：Ashton; Canning Meurer; Cantone; Field; Hannah; Karkas; Liou; Patel; Perry; Wagner; Walton; Tolman Journal of Medicinal Chemistry, 1988 , vol. 31, # 12 p. 2304 - 2315

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被引用次数: 107

摘要

routes to these compounds and several base-modified analogues are presented. The effects of such side-chain alterations and base variations on enzymatic phosphorylation, DNA polymerase inhibition, and inhibition of HSV-1 and HSV-2 replication in cell culture are discussed. Subsequent to the completion of this work, recent reports from other laboratories have described several of the olefinic and acetylenic analogues. 1" 22