Synthesis and pharmacological evaluation of a series of analogs of 1-methylisoguanosine

…, JA Baird-Lambert, BA Baldo, JF Marwood

文献索引：Bartlett; Cook; Holman; McComas; Nowoswait; Poonian; Baird-Lambert; Baldo; Marwood Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 947 - 954

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被引用次数: 31

摘要

A series of analogues of the pharmacologically active marine natural product 1- methylisoguanosine (1) was evaluated for biological activity in muscle relaxant, cardiovascular, antiinflammatory, and antiallergic tests. Modifications at the 1 position produced the ethyl, n-butyl, n-octyl, and phenyl derivatives 3-6, respectively. Substitutions at the 8 position provided the bromo, hydrazino and amino compounds 9-11. Modifications ...