2-Acetylpyridine thiosemicarbazones. 5. 1-[1-(2-Pyridyl) ethyl]-3-thiosemicarbazides as potential antimalarial agents

DL Klayman, JP Scovill, JF Bartosevich…

文献索引：Klayman; Scovill; Bartosevich; Bruce Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 35 - 39

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被引用次数: 190

摘要

Reduction of the azomethine bond of 2-acetylpyridine thio-and selenosemicarbazones with sodium borohydride readily afforded the corresponding thio-or selenosemicarbazides when they were N4, N4-disubstituted. This conversion failed, however, when the thio-or selenosemicarbazones were N4-substituted or unsubstituted. A more general route to the desired thio-or selenosemicarbazides consisted of reduction with sodium borohydride of ...