Tetrahedron Letters

First asymmetric total synthesis of (+)-steganacin determination of absolute stereochemistry

K Tomioka, T Ishiguro, K Koga

文献索引：Tomioka, Kiyoshi; Ishiguru, Tsuneo; Koga, Kenji Tetrahedron Letters, 1980 , vol. 21, p. 2973 - 2976

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被引用次数: 75

摘要

(+)-Steganacin was synthesized in a new and highly specific asymmetric pathway based on the novel application of chiral γ-lactone as a chiral synthon. By this synthesis the absolute stereochemistry of natural (−)-steganacin could be determined in unequivocal way. ... Satisfactory analytical and spectral data were obtained for all compounds. ... Because of unstability of 6 in THF-water system, described two phase system was applied. Addition of crown ether was found to ...