Synthesis and antineoplastic activity of mitosene analogs of the mitomycins

JC Hodges, WA Remers…

文献索引：Hodges, John C.; Remers, William A.; Bradner, William T. Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1184 - 1191

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被引用次数: 29

摘要

A series of 1-substituted mitosene analogues of the mitomycin antitumor antibiotics was prepared by total synthesis and screened for activity against P388 leukemia in mice. In general, analogues with moderately good leaving groups (mostly esters) at the 1 position were active, whereas analogues without such substituents were inactive or barely active. These results lend support to the idea that mitaenes with leaving groupa at position 1 are ...