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Substituted 2-(2-hydroxyphenyl) benzimidazoles as potential agents for the control of periodontal diseases

RA Coburn, MT Clark, RT Evans…

文献索引:Coburn, Robert A.; Clark, Michael T.; Evans, Richard T.; Genco, Robert J. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 205 - 208

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被引用次数: 56

摘要

Results Although 2-phenylbenzimidazoles are usually prepared by condensation of o- phenylenediamines, or their salts, with benzoic acids, esters, or acid chlorides, as well as benzaldehydes or benzonitriles, the method of Tachikawa et al. 13 is useful for the preparation of o-hydroxyphenyl derivatives. Failure to protect the o-hydroxy group results in very low or no yield of the desired products. The minimum bactericidal concentrations of ...