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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis, cell-growth inhibition, and antitumor screening of 2-(pn-butylanilino) purines and their nucleoside analogs

GE Wright, L Dudycz, Z Kazimierczuk…

文献索引：Wright, George E.; Dudycz, Lech W.; Kazimierczuk, Zygmunt; Brown, Neal C.; Khan, Naseema N. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 109 - 116

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被引用次数: 33

摘要

Derivatives of N2-(pn-butylpheny1) guanine (BuPG) and 2-(pn-butylanilino) adenine (BuAA) were synthesized and tested as inhibitors of mammalian DNA polymerase a, cell growth, and macromolecule synthesis. 2-(pn-Butylanilino)-6-chloropurine (BuAC1) served as a useful intermediate to prepare a series of 6-substituted analogues. BuACI, as its sodium salt, reacted with 2-deoxy-3, 5-di-p-toluoyl-~-~-ribofuranosyl chloride in acetonitrile to give 64 ...

4-正丁基苯胺结构式

4-正丁基苯胺

~%

N-(4-butylphenyl)-7H-purin-2-amine结构式

N-(4-butylpheny...

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2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~%

N-(4-butylphenyl)-7H-purin-2-amine结构式

N-(4-butylpheny...

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4-正丁基苯胺结构式

4-正丁基苯胺

~%

2-(4-butylanilino)-9-(2-hydroxyethoxymethyl)-3H-purine-6-thione结构式

2-(4-butylanili...

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2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~%

2-(4-butylanilino)-9-(2-hydroxyethoxymethyl)-3H-purine-6-thione结构式

2-(4-butylanili...

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(2R,3S,5S)-5-[2-(4-butylanilino)-6-chloropurin-9-yl]-2-(hydroxymethyl)oxolan-3-ol结构式

(2R,3S,5S)-5-[2...

~78%

(2R,3S,5S)-5-[2-(4-butylanilino)purin-9-yl]-2-(hydroxymethyl)oxolan-3-ol,hydrate结构式

(2R,3S,5S)-5-[2...

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4-正丁基苯胺结构式

4-正丁基苯胺

~%

(2R,3S,5S)-5-[2-(4-butylanilino)purin-9-yl]-2-(hydroxymethyl)oxolan-3-ol,hydrate结构式

(2R,3S,5S)-5-[2...

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2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~%

(2R,3S,5S)-5-[2-(4-butylanilino)purin-9-yl]-2-(hydroxymethyl)oxolan-3-ol,hydrate结构式

(2R,3S,5S)-5-[2...

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未登录结构式

~87%

2-(4-butylanilino)-9-(2-hydroxyethoxymethyl)-3H-purine-6-thione结构式

2-(4-butylanili...

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3-乙基-4-甲基苯胺结构式

3-乙基-4-甲基苯胺

2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~55%

2-(3-ethyl-4-methylanilino)-3,7-dihydropurin-6-one结构式

2-(3-ethyl-4-me...

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未登录结构式

~56%

2-[[6-amino-2-(4-butylanilino)purin-9-yl]methoxy]ethanol,hydrate结构式

2-[[6-amino-2-(...

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4-正丁基苯胺结构式

4-正丁基苯胺

~%

2-[[6-amino-2-(4-butylanilino)purin-9-yl]methoxy]ethanol,hydrate结构式

2-[[6-amino-2-(...

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2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~%

2-[[6-amino-2-(4-butylanilino)purin-9-yl]methoxy]ethanol,hydrate结构式

2-[[6-amino-2-(...

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未登录结构式

~79%

2-[[2-(4-butylanilino)-6-chloropurin-9-yl]methoxy]ethanol结构式

2-[[2-(4-butyla...

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4-正丁基苯胺结构式

4-正丁基苯胺

~%

2-[[2-(4-butylanilino)-6-chloropurin-9-yl]methoxy]ethanol结构式

2-[[2-(4-butyla...

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2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~%

2-[[2-(4-butylanilino)-6-chloropurin-9-yl]methoxy]ethanol结构式

2-[[2-(4-butyla...

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4-正丁基苯胺结构式

4-正丁基苯胺

~%

(2R,3S,5S)-5-[2-(4-butylanilino)-6-chloropurin-9-yl]-2-(hydroxymethyl)oxolan-3-ol结构式

(2R,3S,5S)-5-[2...

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2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~%

(2R,3S,5S)-5-[2-(4-butylanilino)-6-chloropurin-9-yl]-2-(hydroxymethyl)oxolan-3-ol结构式

(2R,3S,5S)-5-[2...

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未登录结构式

~82%

2-(4-butylanilino)-9-(2-hydroxyethoxymethyl)-3H-purin-6-one结构式

2-(4-butylanili...

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4-正丁基苯胺结构式

4-正丁基苯胺

~%

2-(4-butylanilino)-9-(2-hydroxyethoxymethyl)-3H-purin-6-one结构式

2-(4-butylanili...

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2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~%

2-(4-butylanilino)-9-(2-hydroxyethoxymethyl)-3H-purin-6-one结构式

2-(4-butylanili...

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未登录结构式

~81%

2-[[2-(4-butylanilino)purin-9-yl]methoxy]ethanol结构式

2-[[2-(4-butyla...

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4-正丁基苯胺结构式

4-正丁基苯胺

~%

2-[[2-(4-butylanilino)purin-9-yl]methoxy]ethanol结构式

2-[[2-(4-butyla...

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2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~%

2-[[2-(4-butylanilino)purin-9-yl]methoxy]ethanol结构式

2-[[2-(4-butyla...

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甲醇钠结构式

未登录结构式

~93%

2-[[2-(4-butylanilino)-6-methoxypurin-9-yl]methoxy]ethanol,hydrate结构式

2-[[2-(4-butyla...

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4-正丁基苯胺结构式

4-正丁基苯胺

~%

2-[[2-(4-butylanilino)-6-methoxypurin-9-yl]methoxy]ethanol,hydrate结构式

2-[[2-(4-butyla...

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2-溴次黄嘌呤结构式

2-溴次黄嘌呤

~%

2-[[2-(4-butylanilino)-6-methoxypurin-9-yl]methoxy]ethanol,hydrate结构式

2-[[2-(4-butyla...

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Synthesis, cell-growth inhibition, and antitumor screening o...

[Journal of Medicinal Chemistry, , vol. 30, # 1 p. 109 - 116]