Organic letters

Synthesis of spiro-bisperoxyketals

P Ghorai, PH Dussault, C Hu

文献索引：Ghorai, Prasanta; Dussault, Patrick H.; Hu, Chunhua Organic Letters, 2008 , vol. 10, # 12 p. 2401 - 2404

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被引用次数: 50

摘要

Syntheses of spirocyclic bis-1, 2-dioxolanes, bis-1, 2-dioxanes, and bis-1, 2-dioxepanes are achieved through intramolecular ketalizations of hydroperoxy ketones or intramolecular alkylations of gem-dihydroperoxides. The spiroperoxides have excellent thermal and chemical stability, and several display promising activity against P. falciparum.