A modular flow reactor for performing Curtius rearrangements as a continuous flow process
M Baumann, IR Baxendale, SV Ley, N Nikbin…
文献索引：Baumann, Marcus; Baxendale, Ian R.; Ley, Steven V.; Nikbin, Nikzad; Smith, Christopher D.; Tierney, Jason P. Organic and Biomolecular Chemistry, 2008 , vol. 6, # 9 p. 1577 - 1586
The Curtius rearrangement is synthetically a very powerful transformation for converting carboxylic acid moieties into their chemically diametric amino functionalities. 1 As a direct chemical interconversion this process has tremendous value, but it also has an important strategic impact because of the prevalence of the amide linkage in many pharmaceutical compounds. The transposition of the coupling partners in an amide bond is a classical medicinal chemistry tactic to facilitate ...
