Abstract An efficient method involving a formal hydrohydrazination/Fischer indolization tandem reaction to synthesize 2, 3-disubstituted indoles from alkynes and arylhydrazines has been developed. The approach uses a Ph 3 PAuNTf 2/pTSA· H 2 O binary catalytic system in which a very low catalyst loading of Ph 3 PAuNTf 2 (2 mol-%) is required. The reaction time is very short and, most importantly, the reaction is not sensitive to moisture. ...
