Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents

BP Bandgar, SS Gawande, RG Bodade…

文献索引：Bandgar, Babasaheb P.; Gawande, Shrikant S.; Bodade, Ragini G.; Totre, Jalinder V.; Khobragade, Chandrahas N. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 3 p. 1364 - 1370

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被引用次数: 179

摘要

Chalcones have been identified as interesting compounds with cytotoxicity, anti- inflammatory and antioxidant properties. In the present study, simple methoxychalcones were synthesized by Claisen–Schmidt condensation reaction and evaluated for above biological activities. The structures of the compounds were established by IR, 1H NMR and mass spectral analysis. The data revealed that compound 3s (99–100% at 10μM ...