2-Nitroimidazole dual-function bioreductive drugs: studies on the effects of regioisomerism and side-chain structural modifications on differential cytotoxicity and …
…, MD Threadgill, P Webb, IJ Stratford…
文献索引：Naylor, Matthew A.; Threadgill, Michael D.; Webb, Paul; Stratford, Ian J.; Stephens, Miriam A.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3573 - 3578
(RSU-1069, 1) is the most effective of a large number of nitroheterocyclic compounds that have been synthesized and evaluated as radiosensitizers and bioreductively-activated cyt~ toxins.~-~ Compounds of this type owe their selective cytotoxicity toward hypoxic cells within tumors to their bioreductive properties. Activation in vivo is by anaerobic enzymatic reduction to toxic metabolite^.^ The radiosensitizing activity of 2-nitroimidazoles is via fast ...
