Indoline analogs of idazoxan: potent. alpha. 2-antagonists and. alpha. 1-agonists
GP Fagan, CB Chapleo, AC Lane…
文献索引：Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; et al Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 944 - 948
The synthesis and a-adrenergic activity of a series of substituted 2-imidazolinylindolines are described. Substitution in the indoline ring generated compounds with a spectrum of adrenoceptor antagonist/agonist profiles that proved sensitive to both the nature and position of the substituent. Many of the derivatives possess greater presynaptic antagonist potency than the corresponding benzodioxan 1, dihydrobenzofuran 2, and indan 3 ...
![Propanoic acid,2-[2-(4-chlorophenyl)hydrazinylidene]-, ethyl ester结构式](https://image.chemsrc.com/caspic/306/5296-86-6.png)
