Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences
LH Lash, W Qian, DA Putt, SE Hueni, AA Elfarra…
文献索引：Lash; Qian; Putt; Hueni; Elfarra; Krause; Parker Journal of Pharmacology and Experimental Therapeutics, 2001 , vol. 297, # 1 p. 155 - 164
Abstract Acute cytotoxicity (lactate dehydrogenase release) of trichloroethylene (TRI), S-(1, 2- dichlorovinyl) glutathione (DCVG), andS-(1, 2-dichlorovinyl)-l-cysteine (DCVC) in freshly isolated renal cortical cells and hepatocytes from male and female rats was evaluated to test the hypothesis that the assay provides a valid indicator of sex-and tissue-dependent differences in sensitivity to TRI and its metabolites. We then determined mitochondrial ...
