Synthesis and biological activity of selected 2-substituted 6-(. beta.-D-ribofuranosyl) oxazolo [5, 4-d] pyrimidin-7-ones

…, DS Wise, LB Townsend, A Bloch

文献索引：Patil; Wise; Townsend; Bloch Journal of Medicinal Chemistry, 1974 , vol. 17, # 12 p. 1282 - 1285

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被引用次数: 14

摘要

Several 2-substituted 6-(~-o-ribofuranosyl) oxazolo [~, 4-d] pyrimidin-7-ones have been prepared by condensation of the appropriate silylated heterocyles with 2, 3, 5-tri-O-acetyl-/3- ~-ribofuranosyl bromide and the subsequent removal of blocking groups from the carbohydrate moiety with methanolic ammonia. The site of ribosylation was established by comparison of the uv spectra of the nucleosides with that of an appropriate model ...