A study of the preparation of numerous heterocyclic compounds carrying guanidine substituents has been initiated in this Laboratory. The 2-guanidinoquinazolines are felt to be of special interest since, when appropriately substituted, they embody the skeleton present in Paludrine. Initial attempts at preparation from Z-aminoquinazolines were abandoned when these compounds were found to resist the action of cyanogen bromide, Cyanamides ...
