2, 4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms

…, DP Baccanari, CW Sigel, D DeAngelis…

文献索引：Roth; Tidwell; Ferone; Baccanari; Sigel; DeAngelis; Elwell Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1949 - 1958

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被引用次数: 6

摘要

A series of 2, 4-diamino-5-(3, 5-dialkenyl-4-methoxy-or-4-hydroxybenzy1) pyrimidines was prepared from [(allyloxy) benzyl] pyrimidines by Claisen rearrangements, and the resulting allyl phenols were further modified by methylation and rearrangement to 1-propenyl analogues. Analogous 3, 4-dimethoxy-5-alkenyl derivatives were prepared by similar techniques. High in vitro antibacterial activity was obtained against certain anaerobic ...