Abstract: The reaction of ethyl 2-oxo-2H-chromene-3-carboxylate with hydrazine followed by condensation of the resulting hydrazone with different aromatic aldehydes give the corresponding Schiff bases 5a-e. Reaction of these Schiff bases with mercaptoacetic acid furnishes the target thiazolidinone molecules 6a-e. The newly synthesized compounds have been screened for antibacterial and analgesic activities.