Il Farmaco

Antiparasitic activity of highly conjugated pyrimidine-2, 4-dione derivatives

…, A Gellis, C Di Giorgio, P Vanelle, P Timon-David

文献索引：Azas, Nadine; Rathelot, Pascal; Djekou, Serge; Delmas, Florence; Gellis; Di Giorgio, Carole; Vanelle, Patrice; Timon-David, Pierre Farmaco, 2003 , vol. 58, # 12 p. 1263 - 1270

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被引用次数: 47

摘要

4-[2-(1, 3-Dimethyl-5-nitro-2, 6-dioxo-1, 2, 3, 6-tetrahydropyrimidin-4-yl) vinyl] benzaldehyde was synthesized in four steps from 6-methyl-1H, 3H-pyrimidine-2, 4-dione. This aldehyde was functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum compared to their toxicity versus human ...